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Boc-Asp(OMe)-fluoromethyl ketone

CAS No. 187389-53-3

Boc-Asp(OMe)-fluoromethyl ketone( Boc-Asp(OMe)-FMK )

Catalog No. M28220 CAS No. 187389-53-3

Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Boc-Asp(OMe)-fluoromethyl ketone
  • Note
    Research use only, not for human use.
  • Brief Description
    Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.
  • Description
    Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.(In Vitro):Boc-Asp(OME)-Fluoromethyl Keton (100 μM; 30 minutes; Polymorphonuclear leukocytes) prevents Fas-induced and spontaneous apoptosis . Boc-Asp(OME)-Fluoromethyl Keton (20 μM; 5 hours; J774.1/JA-4 cells) significantly increases LDH release .
  • In Vitro
    Boc-Asp(OME)-Fluoromethyl Keton (100 μM; 30 minutes; Polymorphonuclear leukocytes) prevents Fas-induced and spontaneous apoptosis (?CH-11). Boc-Asp(OME)-Fluoromethyl Keton (20 μM; 5 hours; J774.1/JA-4 cells) significantly increases LDH release.
  • In Vivo
    ——
  • Synonyms
    Boc-Asp(OMe)-FMK
  • Pathway
    Apoptosis
  • Target
    Caspase
  • Recptor
    photosynthetic electron transport chain
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    187389-53-3
  • Formula Weight
    263.265
  • Molecular Formula
    C11H18FNO5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 100 mg/mL (379.85 mM)
  • SMILES
    COC(=O)CC(NC(=O)OC(C)(C)C)C(=O)CF
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shizong Wang, et al. Identification of Degradation Routes of Metamitron in Soil Microcosms Using 13 C-isotope Labeling. Environ Pollut. 2017 Jan;220(Pt B):927-935.
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